The most targeted mitochondrial peptide available. Binds directly to cardiolipin on the inner mitochondrial membrane, stabilizing electron transport chain function at the organelle level.
SS-31 is a cell-permeable tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that concentrates in mitochondria at 1000-5000x plasma levels. It binds to cardiolipin, a phospholipid unique to the inner mitochondrial membrane, stabilizing the electron transport chain and reducing reactive oxygen species production. This improves ATP production efficiency while reducing oxidative damage — addressing mitochondrial dysfunction at its source.
Mitochondrial function declines with age and is further impacted by hormonal changes during perimenopause. SS-31 targets energy production at the organelle level — more precisely than NAD+ or CoQ10 supplementation. It represents the cutting edge of mitochondrial medicine and is currently in clinical trials for conditions including heart failure, kidney disease, and mitochondrial myopathy.
Clinical trial data shows generally good tolerability. Injection site reactions are the most common side effect. As an investigational compound, long-term safety data is still being collected through ongoing clinical trials.
SS-31 (elamipretide) is currently in clinical trials and is not FDA-approved for any indication. It is being studied for heart failure, Barth syndrome, and other mitochondrial conditions.
NAD+ and CoQ10 support mitochondrial function broadly. SS-31 binds directly to cardiolipin on the inner mitochondrial membrane, stabilizing electron transport chain complexes at the source. It is the most precisely targeted mitochondrial intervention available.
Part of our Energy & Longevity hub.
Medical Disclaimer: This profile is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide therapy.
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