The only peptide FDA-approved specifically for women. Treats hypoactive sexual desire disorder (HSDD) in premenopausal women under the brand name Vyleesi.
PT-141 activates melanocortin receptors (MC3R and MC4R) in the central nervous system, triggering sexual desire through neurological pathways rather than vascular mechanisms. Unlike sildenafil (which increases blood flow), PT-141 acts on the brain's desire circuitry — making it fundamentally different from erectile dysfunction drugs repurposed for women.
PT-141 is the flagship differentiator for FemPeptides because it is literally the only peptide with an FDA-approved indication designed for women. Approved in 2019 as Vyleesi, it treats HSDD — a condition affecting an estimated 1 in 10 premenopausal women. The RECONNECT Phase III trials demonstrated statistically significant improvements in sexual desire with a favorable safety profile.
The most common side effect is nausea (~40% of patients), which typically resolves with repeated use. Flushing, headache, and injection site reactions are also reported. PT-141 is administered as a subcutaneous injection at least 45 minutes before anticipated sexual activity, with no more than one dose per 24 hours and no more than 8 doses per month.
This peptide is part of our Sexual Wellness hub — explore all peptides for this use case.
Yes — PT-141 (bremelanotide) was FDA-approved in 2019 under the brand name Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women. It is the only peptide with an FDA-approved indication specifically for women.
PT-141 acts on melanocortin receptors in the brain to stimulate desire, while Viagra increases blood flow. PT-141 targets the neurological desire pathway — it addresses wanting, not just physical response.
Nausea is the most common side effect, affecting about 40% of users but typically improving with repeated use. Flushing, headache, and injection site reactions are also reported. No more than 8 doses per month is recommended.
Medical Disclaimer: This profile is for educational purposes only. It is not medical advice, a treatment recommendation, or a prescription guide. Always consult a licensed healthcare provider before starting any peptide therapy. Evidence ratings reflect the current state of published research and may change as new data emerges.
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